Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Progesterone vs no treatment or placebo (route of progesterone administration)

Live birth or ongoing pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in live birth/ongoing pregnancy rate compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Miscarriage per clinical pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in miscarriage per clinical pregnancy compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Clinical pregnancy · women trying to conceive by intrauterine insemination

Progesterone may leads to higher clinical pregnancy per woman compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes ongoing pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes miscarriage rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Clinical pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes clinical pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist vs placebo/no treatment

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether subcutaneous (Sc) gonadotropin‐releasing hormone (GnRH) agonist changes multiple pregnancy rate compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Clinical pregnancy per woman ‐ oral route · women trying to conceive by intrauterine insemination

It is very uncertain whether progesterone changes clinical pregnancy per woman ‐ oral route compared with no treatment or placebo (route of progesterone administration) (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in multiple pregnancy per woman compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review