Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Number of (minor aphthous) oral ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Colchicine (0.5 mg per day for 3 months) showed no clear difference in number of aphthous ulcers at completion compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Recurrence · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Colchicine (0.5 mg per day for 3 months) showed no clear difference in recurrence during treatment period compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

1 finding from 1 review

Altered-cast technique RDP vs One-piece cast RDP

Patients with increased abutment tooth mobility · Partially edentulous patients treated with a distal-extension RDP

Altered-cast technique RDP showed no clear difference in patients with increased abutment tooth mobility compared with one-piece cast RDP; GRADE not reported.

1 finding from 1 review

Human placental extract vs Disprin (aspirin/betamethasone)

Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Human placental extract led to higher improvement in mucositis compared with disprin (aspirin/betamethasone); GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in disease free survival compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in locoregional control compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Prosthesis failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in prosthesis failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… led to lower aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review