Findings

What do systematic reviews say?

2,922 questions · 3,118 findings · 513 reviews

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No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Gingival index (GI) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, alone or with… showed no clear difference in gingival index compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
MD -28.00 [-144.13, 88.13]
1 study · 53 participants
GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Adverse effects of therapy: Not reported for this comparison.
0 studies
No studies found

Enalapril plus folic acid vs enalapril

Stroke · patients with hypertension

Enalapril plus folic acid leads to lower stroke compared with enalapril (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.79 [0.68, 0.93]
1 study · 20702 participants
High

Enalapril plus folic acid vs enalapril

First unstable angina pectoris episode requiring hospitalisation · patients with hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Enalapril plus folic acid vs enalapril

Death from any cause · patients with hypertension

Enalapril plus folic acid showed no clear difference in death from any cause compared with enalapril (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.94 [0.81, 1.1]
1 study · 20702 participants
High

Enalapril plus folic acid vs enalapril

Serious adverse event (cancer) · patients with hypertension

Enalapril plus folic acid showed no clear difference in serious adverse event (cancer) compared with enalapril (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.96 [0.71, 1.31]
1 study · 20243 participants
Moderate

Enalapril plus folic acid vs enalapril

Myocardial infarction · patients with hypertension

Enalapril plus folic acid showed no clear difference in myocardial infarction compared with enalapril (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 1.04 [0.6, 1.82]
1 study · 20702 participants
Moderate

Intervention not reported

Systolic blood pressure clinical digital sphygmomanometer · adults with or without hypertension

1 finding from 1 review

Effect of cocoa on blood pressure 2017 · Cochrane Headline outcomes only
no estimate extracted
35 studies · 1804 participants
Moderate

Intervention not reported

Diastolic blood pressure clinical digital sphygmomanometer · adults with or without hypertension

1 finding from 1 review

Effect of cocoa on blood pressure 2017 · Cochrane Headline outcomes only
no estimate extracted
34 studies · 1772 participants
Moderate

Intervention not reported

Withdrawals due to adverse effects · adults with or without hypertension

1 finding from 1 review

Effect of cocoa on blood pressure 2017 · Cochrane Headline outcomes only
no estimate extracted
31 studies · 1514 participants
Moderate

Intervention not reported

Proportion of participants with IOP < 21 mmHg at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Mean IOP change from baseline at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Participant‐reported outcomes related to the ease, convenience, and comfort of instillation at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Physiologic measurements of systemic absorption at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Escalation of therapy at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Mean change in visual fields at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse events at 1 year' · participants with glaucoma or ocular hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Topical medication instillation techniques for glaucoma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Preterm birth < 35 weeks · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Preterm births < 35 weeks reported in four studies across three subcomparisons; none of the subcomparisons showed a difference; SRP versus alternative mechanical treatment not pooled due to considerable heterogeneity;…
4 studies
Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Probing pocket depth · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, alone or with… led to lower probing depth compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
MD -0.93 [-1.12, -0.74]
1 study · 53 participants
GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Small‐for‐gestational age · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Small for gestational age: Not reported for this comparison.
0 studies
No studies found