Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,536 questions · 2,637 findings · 315 reviews

No studies found 608 · 23.1%GRADE not reported 488 · 18.5%Very low 688 · 26.1%Low 540 · 20.5%Moderate 249 · 9.4%High 64 · 2.4%

Nutritional supplement (500ml) and standard diet vs standard diet

Six months mortality after liver transplantation (ITT) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes six months mortality after liver transplantation (ITT) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Mild acute rejection episodes (within 6 months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes mild acute rejection episodes (within 6 months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Severe acute rejection episodes (within six months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes severe acute rejection episodes (within six months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Complications and side effects · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement led to lower complications and side effects compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement showed no clear difference in recurrence of peri-implantitis compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement showed no clear difference in change in probing pocket depth (PPD) compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Change in gingival recession (REC) · People with at least one dental implant affected by perimplantitis

Nanocrystalline hydroxyapatite (Ostim) showed no clear difference in change in gingival recession (REC) compared with bovine-derived xenograft (Bio-Oss) plus resorbable barrier; GRADE not reported.

1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Reported pain (mm on VAS) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower reported pain (mm on VAS) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review

Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis

Nanocrystalline hydroxyapatite (Ostim) showed no clear difference in recurrence of peri-implantitis compared with bovine-derived xenograft (Bio-Oss) plus resorbable barrier; GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Number of (minor aphthous) oral ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Colchicine (0.5 mg per day for 3 months) showed no clear difference in number of aphthous ulcers at completion compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Colchicine (0.5 mg per day for 3 months) vs prednisolone

Recurrence · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Colchicine (0.5 mg per day for 3 months) showed no clear difference in recurrence during treatment period compared with prednisolone (5 mg per day for 3 months); GRADE not reported.

1 finding from 1 review

Altered-cast technique RDP vs One-piece cast RDP

Patients with increased abutment tooth mobility · Partially edentulous patients treated with a distal-extension RDP

Altered-cast technique RDP showed no clear difference in patients with increased abutment tooth mobility compared with one-piece cast RDP; GRADE not reported.

1 finding from 1 review

Human placental extract vs Disprin (aspirin/betamethasone)

Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Human placental extract led to higher improvement in mucositis compared with disprin (aspirin/betamethasone); GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in disease free survival compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review