Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Brivaracetam vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

Brivaracetam probably leads to higher 50% or greater reduction in seizure frequency (responder rate) compared with placebo (moderate certainty).

1 finding from 1 review

Brivaracetam vs placebo

Withdrawals due to adverse events · people with drug‐resistant focal epilepsy

Brivaracetam may leads to higher proportion of participants who experienced adverse events leading to… compared with placebo (low certainty).

1 finding from 1 review

Brivaracetam vs placebo

Adverse events as N of participants with at least one adverse event objective · people with drug‐resistant focal epilepsy

Brivaracetam showed no clear difference in proportion of participants who experienced any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled NO vs placebo

Frequency of pain crises in the · people with SCD

Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty).

2 findings from 1 review