Systolic blood pressure · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Systolic blood pressure: WMD -2.39 (95% CI -5.7 to 0.9), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD -2.39 [-5.7, 0.9]
3 studies
GRADE not reported
Patient perception: pain · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
1 finding from 1 review
Self-reported pain on insertion (0-4 scale): pre-drilling mean 0.73 (SD 1.1; median 0.00, IQR 0-3) vs self-drilling mean 1.87 (SD 1.13; median 2.0, IQR 0-4); 1 study (Lehnen 2011), 30 participants
1 study · 30 participants
GRADE not reported
Risk of hyperphosphataemia · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.58 (95% CI 0.47 to 5.30), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Maternal vitamin D concentrations at term: WMD 47.08 (95% CI 23.76 to 70.39), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
WMD 47.08 [23.76, 70.39]
4 studies
GRADE not reported
Bone mineral density · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density (Whole body / total), Healthy children: SMD 0.1 (95% CI -0.06 to 0.26), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.1 [-0.06, 0.26]
5 studies
GRADE not reported
Hip/femoral bone mineral density (BMD) · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in hip, Healthy children: SMD 0.06 (95% CI -0.18 to 0.29), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.06 [-0.18, 0.29]
4 studies
GRADE not reported
Bone pain · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Bone pain: RR 0.29 (95% CI 0.03 to 2.63), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Bone mineral density · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density, Community-dwelling adults: WMD -0.9 (95% CI -2.10 to 0.40), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -0.9 [-2.10, 0.40]
3 studies
GRADE not reported
Dental caries · children
Meta-analysis of randomised trials of vitamin D supplementation for Dental caries: RR 0.53 (95% CI 0.43 to 0.65), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
All cause mortality (in CKD patients) · Participants in observational studies
The meta-analysis of observational studies reported a RR of 0.88 (95% CI 0.81 to 0.93) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Insulin resistance · Adults with diabetes
Meta-analysis of randomised trials of vitamin D supplementation for Insulin resistance (Diabetes): SMD 0.16 (95% CI -0.11 to 0.42), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
SMD 0.16 [-0.11, 0.42]
5 studies
GRADE not reported
Type 2 diabetes (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes (prevalent): OR 0.45 (95% CI 0.25 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Adverse effects · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
The review found no eligible studies for this question.
1 finding from 1 review
All cause mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Economic factors · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)
The review found no eligible studies for this question.
1 finding from 1 review
Rectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Relative DOR by setting (FC, advanced, occlusal permanent) · Permanent teeth, occlusal surfaces, with suspected caries lesions
No significant setting difference for FC (RDOR 2.96, 0.36 to 24.45).
2 findings from 1 review
More advanced caries lesion detection · Primary teeth with approximal surfaces
Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=89%; no GRADE rating was reported.
2 findings from 1 review
Healthcare costs: cost-effectiveness of fee-for-service vs control (incremental cost-effectiveness ratio, reported as % change in outcome per GBP; currency year NR) · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…
1 finding from 1 review
Measures of non-clinical behaviour: proportion of dentists introducing innovations into their dental practices · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…
Capitation remuneration led to lower measures of non-clinical behaviour: proportion of dentists… compared with fee-for-service remuneration; GRADE not reported.
1 finding from 1 review
RR 0.81
1 study
GRADE not reported