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What do systematic reviews say?

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Evidence found and GRADE certainty

2,922 questions · 3,118 findings · 513 reviews

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No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

Intervention not reported

Mortality 4 to 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes mortality 4 to 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Total CV events 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes total CV events 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse effects 5 years · Adults with mild hypertension and no cardiovascular disease

The intervention probably leads to higher withdrawals due to adverse effects 5 years (moderate certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Self-reported joint pain when chewing · People with temporomandibular disorders (TMD)

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Depression · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Severity of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes severity of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)

Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Muscle pain when chewing · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes muscle pain when chewing compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Joint pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes joint pain at rest compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

1 finding from 1 review

Smoking cessation advice vs no smoking cessation counselling, grouped by intensity of intervention

Quit at longest · individuals who smoke cigarettes and are admitted to a hospital for medical or surgical care

It is very uncertain whether smoking cessation counselling changes quit at longest compared with no smoking cessation counselling, grouped by intensity of intervention (very low certainty).

4 findings from 1 review
Show 1 more finding

Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure

Wound infection · pilonidal sinus

It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound infection compared with tension‐free midline closure (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure

Wound dehiscence · pilonidal sinus

It is very uncertain whether summary of findings table ‐ Off‐midline closure changes wound dehiscence compared with tension‐free midline closure (very low certainty).

1 finding from 1 review