What do systematic reviews say?

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Summary of findings: Molecular‐targeted therapy plus chemotherapy showed no clear difference in progression‐free survival compared with chemotherapy alone (low certainty).

• Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
  HR 0.9 [0.78, 1.04]
  11 studies · 4014 participants
  Low

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

• Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Summary of findings: Molecular‐targeted therapy plus chemotherapy showed no clear difference in overall response rate Duration of compared with chemotherapy alone (low certainty).

• Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
  OR 1.24 [1, 1.55]
  11 studies · 3723 participants
  Low

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher adverse event (any) Duration of compared with chemotherapy alone (moderate certainty).

• Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
  OR 2.23 [1.27, 3.92]
  5 studies · 2290 participants
  Moderate

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher severe adverse event (grade ≥ 3 ) Duration of compared with chemotherapy alone (moderate certainty).

• Molecular‐targeted first‐line therapy for advanced gastric cancer 2016 · Cochrane Headline outcomes only
  OR 1.19 [1.03, 1.37]
  8 studies · 3800 participants
  Moderate

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Percutaneous endoscopic gastrostomy may leads to lower treatment failure Feeding interruption, blocking or leakage of the… compared with nasogastric tube feeding (low certainty).

• Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances 2015 · Cochrane Headline outcomes only
  RR 0.18 [0.05, 0.59]
  8 studies · 408 participants
  Low

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

It is very uncertain whether percutaneous endoscopic gastrostomy changes mortality irrespective of compared with nasogastric tube feeding (very low certainty).

• Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances 2015 · Cochrane Headline outcomes only
  RR 0.86 [0.58, 1.28]
  9 studies · 644 participants
  Very low

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Percutaneous endoscopic gastrostomy showed no clear difference in pneumonia irrespective of compared with nasogastric tube feeding (low certainty).

• Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances 2015 · Cochrane Headline outcomes only
  RR 0.7 [0.46, 1.06]
  7 studies · 645 participants
  Low

Percutaneous endoscopic gastrostomy vs nasogastric tube feeding

Percutaneous endoscopic gastrostomy showed no clear difference in adverse events irrespective of compared with nasogastric tube feeding (moderate certainty).

• Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances 2015 · Cochrane Headline outcomes only
  RR 0.83 [0.51, 1.34]
  6 studies · 597 participants
  Moderate

Drain vs No drain

It is very uncertain whether drain changes 30‐day mortality Death during the compared with no drain (very low certainty).

• Abdominal drainage versus no drainage post‐gastrectomy for gastric cancer 2015 · Cochrane Headline outcomes only
  RR 1.73 [0.38, 7.84]
  4 studies · 438 participants
  Very low

Drain vs No drain

• Abdominal drainage versus no drainage post‐gastrectomy for gastric cancer 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 4 participants
  Low

Drain vs No drain

It is very uncertain whether drain changes re‐operations Re‐operations during the compared with no drain (very low certainty).

• Abdominal drainage versus no drainage post‐gastrectomy for gastric cancer 2015 · Cochrane Headline outcomes only
  RR 2.49 [0.71, 8.74]
  2 studies · 230 participants
  Very low

Drain vs No drain

• Abdominal drainage versus no drainage post‐gastrectomy for gastric cancer 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 378 participants
  Low

Drain vs No drain

• Abdominal drainage versus no drainage post‐gastrectomy for gastric cancer 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 438 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes the toxic and side effects in digestive system after chemotherapy… (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 0.43 [0.28, 0.66]
  6 studies · 388 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes the rate of complete remission and partly remission (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 1.48 [0.78, 2.81]
  3 studies · 153 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes the toxic and side effects in digestive system after chemotherapy (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 1.13 [0.18, 7.24]
  3 studies · 153 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 0.37 [0.18, 0.74]
  3 studies · 153 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes the rate of complete remission and partly remission (Copy) (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 1.48 [1.01, 2.17]
  7 studies · 448 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy(no… (very low certainty).

• Chinese herbal medicines for induction of remission in advanced or late gastric cancer 2013 · Cochrane Headline outcomes only
  OR 0.32 [0.21, 0.5]
  6 studies · 388 participants
  Very low