Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

707 questions · 732 findings · 77 reviews

No studies found 168 · 23%GRADE not reported 85 · 11.6%Very low 292 · 39.9%Low 149 · 20.4%Moderate 35 · 4.8%High 3 · 0.4%

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

Psychological intervention + palatal arch vs Psychological intervention + palatal crib

Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)

Psychological intervention + palatal arch led to lower sucking cessation (short term) compared with psychological intervention + palatal crib; GRADE not reported.

1 finding from 1 review

Psychological intervention (positive reinforcement) vs Alternative psychological intervention (negative reinforcement)

Sucking cessation (long term) · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy probably leads to lower acceptability 1 ‐ proportion of participants withdrawing during… compared with usual care or waiting list (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy may leads to higher treatment response at end of treatment CGI‐improvement/Global… compared with usual care or waiting list (low certainty).

1 finding from 1 review

Psychological therapy vs enhanced or structured care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy showed no clear difference in acceptability 1 ‐ proportion of participants withdrawing during… compared with enhanced or structured care (moderate certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

Diagnosis of PTSD after treatment · various

It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

PTSD diagnosis · various

Any early psychological intervention may leads to lower PTSD diagnosis: 3–6 months compared with waiting list/usual care (low certainty).

2 findings from 1 review