Hypercalcaemia · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hypercalcaemia: RR 3.80 (95% CI 0.90 to 16.12), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Femoral neck bone mineral density (FN-BMD) · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in femoral neck, Community-dwelling adults: WMD 1.10 (95% CI 0.40 to 1.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD 1.10 [0.40, 1.90]
8 studies
GRADE not reported
Lumbar spine bone mineral density (BMD) · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in lumbar spine, Community-dwelling adults: WMD 0.10 (95% CI -0.60 to 0.70), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
WMD 0.10 [-0.60, 0.70]
7 studies
GRADE not reported
Non‐vertebral fractures · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, People aged >65 years: RR 0.79 (95% CI 0.63 to 0.99), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Muscle strength · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: muscle strength, Older adults: SMD -0.19 (95% CI -0.35 to -0.02), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
SMD -0.19 [-0.35, -0.02]
3 studies
GRADE not reported
Fractures: non-vertebral, non-hip · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, non-hip, Older women: OR 0.69 (95% CI 0.21 to 1.66), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
OR 0.69 [0.21, 1.66]
2 studies
GRADE not reported
Diastolic blood pressure · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Diastolic blood pressure: WMD -0.03 (95% CI -1.98 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD -0.03 [-1.98, 1.92]
3 studies
GRADE not reported
Gestational age at birth (weeks) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Mean gestational age at delivery: WMD 0.17 (95% CI -0.16 to 0.51), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 0.17 [-0.16, 0.51]
2 studies
GRADE not reported
Subperiosteal erosions · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Subperiosteal erosions: RR 0.41 (95% CI 0.07 to 2.38), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.40 (95% CI 0.38 to 5.15), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Small‐for‐gestational age · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Small for gestational age: RR 0.67 (95% CI 0.40 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Creatinine clearance · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Creatinine clearance: WMD -1.68 (95% CI -6.92 to 3.56), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -1.68 [-6.92, 3.56]
4 studies
GRADE not reported
Risk of hyperphosphataemia · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.57 (95% CI 0.97 to 2.54), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Fracture · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: RR 1.00 (95% CI 0.06 to 15.41), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
RR 1.00 [0.06, 15.41]
4 studies
GRADE not reported
Hypercalcaemia · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hypercalcaemia: RR 3.04 (95% CI 1.17 to 7.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Bone mineral density in forearm · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in forearm, Healthy children: SMD 0.04 (95% CI -0.36 to 0.45), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.04 [-0.36, 0.45]
3 studies
GRADE not reported
Preterm birth · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Preterm delivery: RR 0.77 (95% CI 0.35 to 1.66), not statistically significant.
1 finding from 1 review
Fractures: vertebral or deformity · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: vertebral or deformity, Men aged >65 years and postmenopausal women: RR 0.90 (95% CI 0.42 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Cholesterol mg/dL · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Total cholesterol: WMD 1.52 (95% CI -1.42 to 4.46), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 1.52 [-1.42, 4.46]
11 studies
GRADE not reported
Parathyroid hormone · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroid hormone: WMD -196.05 (95% CI -298.43 to -93.66), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review