evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

748 questions · 782 findings · 58 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 164 · 21%GRADE not reported 26 · 3.3%Very low 151 · 19.3%Low 222 · 28.4%Moderate 158 · 20.2%High 61 · 7.8%

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with chemotherapy vs chemotherapy alone

Progression‐free survival · newly‐diagnosed EOC

It is very uncertain whether summary of findings table ‐ Newly‐diagnosed EOC: PARPi with… changes progression‐free survival (PFS) compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with chemotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with… leads to higher any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with chemotherapy alone (high certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Death at 1 year · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) showed no clear difference in death at 1 year compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Complete or substantial improvement of condition · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) may leads to higher complete or substantial improvement of condition compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Visual disturbances · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) leads to higher visual disturbances compared with control without HBOT (high certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Complete resolution or significant improvement of osteoradionecrosis · any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw

Hyperbaric oxygen therapy (HBOT) showed no clear difference in complete resolution or significant improvement of osteoradionecrosis compared with control without HBOT (low certainty).

1 finding from 1 review

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI maintenance vs chemotherapy alone

Overall survival (OS) · newly‐diagnosed EOC

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI… showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI maintenance vs chemotherapy alone

Progression‐free survival (PSF) · newly‐diagnosed EOC

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI… showed no clear difference in progression‐free survival (PSF) compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI maintenance vs chemotherapy alone

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

Chemotherapy with TKI (peptide‐Fc fusion protein) followed by TKI… probably leads to lower any adverse event grade ≥ 3 compared with chemotherapy alone (moderate certainty).

1 finding from 1 review