Findings

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Evidence found and GRADE certainty

230 questions · 235 findings · 17 reviews

No studies found 71 · 30.2%GRADE not reported 17 · 7.2%Very low 70 · 29.8%Low 49 · 20.9%Moderate 20 · 8.5%High 8 · 3.4%

4% articaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine plain may leads to lower success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

0.5% bupivacaine, 1:200,000 epinephrine may leads to higher speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% articaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • 'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
    2 studies · 74 participants
    GRADE not reported

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine showed no clear difference in adverse effects: pain on injection (solution deposition),… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

4% prilocaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

3% prilocaine, 0.03 IU felypressin probably leads to lower success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine probably leads to higher adverse effects: pain following injection, Heft-Parker VAS 0-170 mm compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review