Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: hypertension compared with oral steroids alone (low certainty).
Calcineurin inhibitors ± oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).
Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: acne compared with oral steroids alone (low certainty).
It is very uncertain whether steroids changes complete or partial remission Time frame: to 77 months compared with no specific treatment (very low certainty).
Mycophenolate sodium + oral steroids showed no clear difference in complete remission Time frame: 4 weeks compared with oral steroids alone (moderate certainty).
Mycophenolate sodium + oral steroids showed no clear difference in complete or partial remission Time frame: 24 weeks to end of treatment compared with oral steroids alone (moderate certainty).
Mycophenolate sodium + oral steroids showed no clear difference in relapse Time frame: 24 weeks compared with oral steroids alone (low certainty).
Mycophenolate sodium + oral steroids showed no clear difference in adverse events: death compared with oral steroids alone (low certainty).
Mycophenolate sodium + oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).
Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).
It is very uncertain whether steroids changes relapse during compared with no specific treatment (very low certainty).
It is very uncertain whether steroids changes adverse events: avascular necrosis compared with no specific treatment (very low certainty).
It is very uncertain whether steroids changes adverse events: doubling serum creatinine compared with no specific treatment (very low certainty).
It is very uncertain whether steroids changes adverse events: kidney failure compared with no specific treatment (very low certainty).
It is very uncertain whether intravenous ± oral steroids changes complete remission Time frame: 2 to 28 months compared with oral steroids alone (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether intravenous ± oral steroids changes relapse during compared with oral steroids alone (very low certainty).
Cyclosporin may leads to higher complete remission of proteinuria compared with different comparators (low certainty).
Cyclosporin showed no clear difference in partial remission of proteinuria compared with different comparators (low certainty).
Cyclosporin may leads to higher complete or partial remission compared with different comparators (low certainty).