Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

484 questions · 512 findings · 35 reviews · Common Mental Disorders

No studies found 137 · 26.8%GRADE not reported 12 · 2.3%Very low 156 · 30.5%Low 136 · 26.6%Moderate 60 · 11.7%High 11 · 2.1%

SSRI antidepressants vs tricyclic antidepressants (TCAs)

Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries

It is very uncertain whether SSRI antidepressants changes drop‐outs (12 weeks) compared with TCA (very low certainty).

1 finding from 1 review

Metformin vs placebo

Fasting blood glucose (mg/dL) · Adults with mental disorders in low‐ and middle‐income countries
2 findings from 1 review

Comparison 1: Individual CBT‐based psychotherapy vs TAU or another comparator

Repetition of SH at post‐intervention · self‐harm in children and adolescents (up to 18 years or age)

Comparison 1: Individual CBT‐based psychotherapy showed no clear difference in repetition of SH by post‐intervention compared with TAU or other comparator (low certainty).

1 finding from 1 review

Family therapy vs placebo

Repetition of SH at post‐intervention · self‐harm in children and adolescents (up to 18 years or age)

Comparison 7: Family therapy showed no clear difference in repetition of SH at post‐intervention compared with placebo (moderate certainty).

1 finding from 1 review

Comparison 7: Structured GP follow‐up vs TAU or another comparator

Repetition of SH at post‐intervention · self‐harm in adults

Comparison 7: Structured GP follow‐up showed no clear difference in repetition of SH at post‐intervention (hospital records) compared with TAU or another comparator (low certainty).

2 findings from 1 review