Mortality (overall survival) · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
Elective neck dissection (at time of primary tumour resection) probably leads to lower mortality (overall survival) compared with therapeutic (delayed) neck dissection (moderate certainty).
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer
Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with elective neck dissection (low certainty).
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
1 finding from 1 review
Locoregional recurrence: data not presented usably and inconsistent; Pandey 2018 no difference (3/12 vs 3/20); Rastogi 2018 lower recurrence with superselective (Kaplan-Meier P<0.05); 72 participants (2 RCTs).
2 studies · 72 participants
Very low
Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Adverse events: severe acute effects in both groups (subcutaneous fibrosis, telangiectasia, moderate-to-severe oedema, xerostomia, trismus, dysphagia); subcutaneous fibrosis more prevalent with surgery + radiotherapy…
1 study · 35 participants
Very low
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
1 finding from 1 review
Locoregional recurrence: reported difference between groups not statistically significant (P=0.355), but no useable data; 32 participants (1 RCT, Iyer 2015).
1 study · 32 participants
Very low
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Disease-free survival · Adults with oral cavity cancer
It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).
1 finding from 1 review
Restoration survival · Children with decayed primary molar teeth
Multi-surface ART restorations had a reported survival rate of 73% at 1 year.
4 findings from 1 review
Survival rate 73
9 studies
GRADE not reported
Survival rate 95
9 studies
GRADE not reported
Survival rate 59
9 studies
GRADE not reported
Show 1 more finding
Survival rate 91
9 studies
GRADE not reported
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Stepwise excavation reduced the reported risk of pulp exposure by 69% versus complete caries removal (RR 0.31; ungraded).
1 finding from 1 review
RR 0.31 [0.17, 0.57]
262 participants
GRADE not reported
Intervention not reported
Pain during treatment
1 finding from 1 review
Restoration failure · Children (2-9 years) with caries in posterior primary teeth
Single-surface ART restorations had a low reported mean annual failure rate (about 5%; ungraded).
1 finding from 1 review
Restoration failure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement
ART with GIC was reported to increase the odds of restoration failure versus conventional restoration (OR 1.60; ungraded).
1 finding from 1 review
Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth
Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).
1 finding from 1 review
RR 0.23 [0.08, 0.69]
2 studies
GRADE not reported
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Partial caries removal reduced the reported risk of pulp exposure versus complete caries removal in primary teeth (RR 0.24; ungraded).
1 finding from 1 review
RR 0.24 [0.06, 0.90]
262 participants
GRADE not reported
Restoration survival · Children with occlusoproximal caries in primary teeth
Multiple reviews reported similar restoration survival for ART versus conventional restorations in occlusoproximal cavities (ungraded).
1 finding from 1 review
Discomfort during treatment · Children (3-10 years) with dentine caries in primary molars
The reported estimate for treatment discomfort with the Hall Technique versus conventional restorations was inconclusive (ungraded).
1 finding from 1 review
RR 1.67 [0.65, 4.25]
2 studies
GRADE not reported
Success or failure of restoration (as defined by the USPHS criteria) · Children with carious primary teeth
ART with high-viscosity GIC and amalgam had similar class I restoration success at 24 months (ungraded).
2 findings from 1 review
RR 1.07 [0.91, 1.27]
3 studies
GRADE not reported
RR 0.93 [0.83, 1.06]
3 studies
GRADE not reported
Restoration survival · Children with decayed primary molar teeth
Single-surface ART/HVGIC restorations had high reported survival (86% at 3 years), significantly higher than multi-surface restorations (ungraded).
1 finding from 1 review
Survival rate (%) 86
9 studies
GRADE not reported