Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

211 questions · 428 findings · 24 reviews

No studies found 1 · 0.2%GRADE not reported 346 · 80.8%Very low 14 · 3.3%Low 24 · 5.6%Moderate 43 · 10%High 0 · 0%

E-cigarette aerosol / e-liquid exposure (flavored and unflavored; nicotine and non-nicotine) vs Unexposed controls / unflavored e-liquid / conventional cigarette smoke

Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…

In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).

1 finding from 1 review

E-cigarette aerosol / e-liquid exposure (flavored and unflavored; nicotine and non-nicotine) vs Unexposed controls / unflavored e-liquid / conventional cigarette smoke

Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…

Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).

1 finding from 1 review

High-viscosity GIC atraumatic restorative treatment vs No control

Restoration survival · Children with decayed primary molar teeth

Multi-surface ART restorations had a reported survival rate of 73% at 1 year.

4 findings from 1 review
Show 1 more finding

Single-surface ART restoration using high-viscosity glass ionomer vs Multi-surface ART with high-viscosity GIC

Restoration failure · Children (2-9 years) with caries in posterior primary teeth

Single-surface ART restorations had a low reported mean annual failure rate (about 5%; ungraded).

1 finding from 1 review

High-viscosity GIC atraumatic restorative treatment vs Conventional restoration

Restoration survival · Children with occlusoproximal caries in primary teeth

Multiple reviews reported similar restoration survival for ART versus conventional restorations in occlusoproximal cavities (ungraded).

1 finding from 1 review

Atraumatic restorative treatment with high-viscosity GIC (class I) vs Amalgam restoration

Success or failure of restoration (as defined by the USPHS criteria) · Children with carious primary teeth

ART with high-viscosity GIC and amalgam had similar class I restoration success at 24 months (ungraded).

2 findings from 1 review

Single-surface ART restoration using high-viscosity glass ionomer vs Multi-surface ART with high-viscosity GIC

Restoration survival · Children with decayed primary molar teeth

Single-surface ART/HVGIC restorations had high reported survival (86% at 3 years), significantly higher than multi-surface restorations (ungraded).

1 finding from 1 review

Multiple-surface ART restoration using high-viscosity glass ionomer vs Single-surface ART with high-viscosity GIC

Restoration survival · Children with decayed primary molar teeth

Multi-surface ART/HVGIC restorations had lower reported survival (49% at 3 years) than single-surface restorations (ungraded).

1 finding from 1 review

Multiple-surface ART restoration using high-viscosity glass ionomer vs Single-surface ART with high-viscosity GIC

Restoration failure · Children (2-9 years) with caries in posterior primary teeth

Multi-surface ART restorations had a high reported mean annual failure rate (17%; ungraded).

1 finding from 1 review

Atraumatic restorative treatment vs Conventional treatment with local anaesthesia

Discomfort associated with the procedure · People with dental caries in primary teeth (mainly children)

The reported estimate for discomfort with ART versus conventional treatment was inconclusive (ungraded).

1 finding from 1 review