Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

351 questions · 362 findings · 10 reviews · Oral medicine and oral cancer

No studies found 41 · 11.3%GRADE not reported 285 · 78.7%Very low 10 · 2.8%Low 18 · 5%Moderate 8 · 2.2%High 0 · 0%

Oral care protocol vs usual care or no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) may leads to lower oral mucositis (any severity) compared with no treatment (low certainty).

1 finding from 1 review

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review