Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

427 questions · 437 findings · 29 reviews · Schizophrenia

No studies found 77 · 17.6%GRADE not reported 61 · 14%Very low 130 · 29.7%Low 103 · 23.6%Moderate 54 · 12.4%High 12 · 2.7%

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Clinical response: global state ‐ no clinical improvement ‐ short term Rates of improvement · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in clinical response: global state ‐ no clinical improvement ‐ short… compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Leaving the study early ‐ short/medium term Rate of attrition · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in leaving the study early ‐ short/medium term Rate of attrition compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short/medium term Numbers requiring anticholinergic medication · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in adverse effects: general ‐ movement disorders ‐ requiring… compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Global state: Response ‐ proxy outcome ‐ mental state: 1. General ‐ average score (Brief Psychiatric Rating Scale by over 24 weeks · patients with schizophrenia or related psychoses

The review found no eligible studies for this question.

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Leaving the study early ‐ short/medium term Rate of attrition · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes leaving the study early ‐ short term Rate of attrition compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short term Numbers requiring anticholinergic medication · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes adverse effects: general ‐ movement disorders ‐ requiring… compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs other depot antipsychotic drugs

Clinical response: mental state ‐ relapse ‐ medium term Relapse rate · patients with schizophrenia or related psychoses

FLUPENTHIXOL DECANOATE showed no clear difference in clinical response: mental state ‐ relapse ‐ medium term Relapse rate compared with OTHER DEPOT ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Movement disorders number of participants receiving antiparkinson medication · patients with schizophrenia

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with other antipsychotics (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

Perazine showed no clear difference in overall tolerability Leaving the study early due to adverse events compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Satisfaction with care ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Quality of life ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Global state change over time (no better or deterioration) · patients with schizophrenia

Perazine showed no clear difference in global state change over time (no better or deterioration) compared with other antipsychotics (low certainty).

1 finding from 1 review