What do systematic reviews say?

Mirtazapine vs tricyclic antidepressants (TCAs)

It is very uncertain whether mirtazapine changes dropouts due to any cause (acceptability) compared with tricyclic antidepressants (TCA) (very low certainty).

• Antidepressants for the treatment of depression in people with cancer 2023 · Cochrane Headline outcomes only
  RR 0.65 [0.2, 2.15]
  1 study · 33 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  HR 0.89 [0.66, 1.19]
  3 studies · 690 participants
  Low

Discontinuation with high‐intensity psychological interventions vs continuation

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  HR 2.09 [1.59, 2.74]
  10 studies · 1373 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 690 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 484 participants
  Low

Discontinuation with high‐intensity psychological interventions vs continuation

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 455 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 106 participants
  Low

Abrupt discontinuation vs continuation of long‐term antidepressants

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 182 participants
  Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 104 participants
  Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  OR 1.11 [0.62, 1.99]
  7 studies · 1012 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 330 participants
  Very low