Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Mineralocorticoid receptor antagonists (MRAs) vs placebo or no treatment

All‐cause mortality · patients with chronic heart failure with preserved ejection fraction

Mineralocorticoid receptor antagonists (MRAs) showed no clear difference in all‐cause mortality compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Colloid vs crystalloid

Neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 · women having spinal anaesthesia for caesarean section

It is very uncertain whether colloid changes neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 compared with crystalloid (very low certainty).

1 finding from 1 review

Ephedrine vs phenylephrine

Neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 · women having spinal anaesthesia for caesarean section

Ephedrine showed no clear difference in neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 compared with phenylephrine (low certainty).

1 finding from 1 review