Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

PIMOZIDE vs placebo

Mental state: no improvement medium term (3‐12 months) not reported · patients with schizophrenia or related psychoses

The review found no eligible studies for this question.

1 finding from 1 review

PIMOZIDE + ANY ANTIPSYCHOTIC vs placebo/no adjunctive treatment + antipsychotics

Global state: relapse medium term (3‐12 months) Clinical diagnoses · patients with schizophrenia or related psychoses

PIMOZIDE + ANY ANTIPSYCHOTIC showed no clear difference in global state: relapse medium term (3‐12 months) compared with ANTIPSYCHOTIC + PLACEBO; GRADE not reported.

1 finding from 1 review

PIMOZIDE vs placebo

Mental state: presence of first‐rank symptoms medium term (3‐12 months) not reported · patients with schizophrenia or related psychoses

The review found no eligible studies for this question.

1 finding from 1 review

PIMOZIDE vs placebo

Adverse effects: extrapyramidal adverse effects Parkinsonism (rigidity) short term (< 3 months) Extrapyramidal Symptom Rating Scale (ESRS) · patients with schizophrenia or related psychoses

It is very uncertain whether PIMOZIDE changes adverse effects: extrapyramidal adverse effects: Parkinsonism… compared with PLACEBO (very low certainty).

1 finding from 1 review

PIMOZIDE vs placebo

Adverse effects: extrapyramidal adverse effects Parkinsonism (rigidity) medium term (3‐12 months) Clinical diagnoses · patients with schizophrenia or related psychoses

It is very uncertain whether PIMOZIDE changes adverse effects: extrapyramidal adverse effects:Parkinsonism… compared with PLACEBO (very low certainty).

1 finding from 1 review