Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Intranasal steroid spray vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes presence/persistence of OME (short‐term); assumed ICC = 0.5 compared with no treatment (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Recurrent ischaemic or unknown stroke during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes recurrent ischaemic/unknown stroke during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Major extracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes major extracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Complete recovery from stroke (post hoc) · acute ischaemic stroke

Antiplatelet drug probably leads to higher complete recovery from stroke (post hoc) compared with control (moderate certainty).

1 finding from 1 review

Analgesic‐decongestant vs placebo

Adverse effects: drowsiness, hypersomnia, lethargy, excessive sleepiness, and other central nervous system adverse effects · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: drowsiness, hypersomnia, lethargy, excessive… compared with placebo (moderate certainty).

1 finding from 1 review

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 3 days of treatment (included children 2 to… compared with placebo (low certainty).

2 findings from 1 review

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation: after 5 days of treatment (included children 2 to 12 years old only) · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 5 days of treatment (included children 2 to… compared with placebo (low certainty).

1 finding from 1 review