Severe hypoglycaemia
Summary of findings: insulin degludec showed no clear difference in severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin detemir (low certainty).
1 finding from 1 review
Non‐fatal myocardial infarction/stroke
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin detemir (low certainty).
1 finding from 1 review
Serious adverse events (n/N)
Summary of findings: insulin degludec showed no clear difference in serious adverse events (n/N) compared with insulin detemir (low certainty).
1 finding from 1 review
HbA1c (%)
1 finding from 1 review
All‐cause mortality
It is very uncertain whether summary of findings: insulin degludec changes all‐cause mortality compared with insulin glargine (very low certainty).
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin detemir probably leads to lower severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Health related quality of life the Uniscale and the Symptom Distress Scale (SDS); Better indicated by lower values
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin degludec showed no clear difference in severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin glargine (low certainty).
1 finding from 1 review
Non‐fatal myocardial infarction/stroke Definition: myocardial infarction/cerebral ischaemia
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring from 22:00 to 06:59 h
Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (low certainty).
1 finding from 1 review
Serious adverse events (n/N)
Summary of findings: insulin degludec showed no clear difference in serious adverse events (n/N) compared with insulin glargine (low certainty).
1 finding from 1 review
HbA1c (%)
1 finding from 1 review
Non‐fatal myocardial infarction/stroke Definition: myocardial infarction
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin detemir showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Serious adverse events (n/N)
Summary of findings: insulin detemir showed no clear difference in serious adverse events (n/N) compared with NPH insulin (moderate certainty).
1 finding from 1 review
Health‐related quality of life Scales: Well‐Being Enquiry for Diabetics; General Well‐being; Diabetes Quality of Life for Youth and Parents' Diabetes Quality of Life
1 finding from 1 review
Intervention not reported
Number of infections
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Number of hospitalisations
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Number of deaths
1 finding from 1 review
no estimate extracted
Studies not reported
Very low