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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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18% CP paint-on gel vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 18% CP paint-on gel changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Chemical cured composite vs Glass ionomer cement (GIC)

Decalcification · Patients with fixed orthodontic appliances attached to their teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Adhesives for fixed orthodontic brackets 2018 · Cochrane All outcomes
    To end of appliance treatment
    It was surprising that decalcification rates were not reported as a secondary outcome, as clinically it is suggested that GIC is protective against decalcification; the…
    0 studies
    No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

Probing pocket depth · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes probing pocket depth (mm) compared with SPT performed by specialists (specialist practice) (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in clinical attachment level (CAL) (mm) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review

Self-management (self-administered/self-monitored OHA) vs Professional OHA

Gingivitis · Children or adults (fit and healthy, or with a well-defined medical condition)

It is very uncertain whether self-management (self-administered/self-monitored OHA) changes periodontal health: gingivitis compared with professional OHA (very low certainty).

1 finding from 1 review

EMP + CAF vs CAF

Keratinized tissue width change · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm)

EMP + CAF led to higher keratinized tissue width change (short and medium term) compared with CAF; GRADE not reported.

2 findings from 1 review

Enamel matrix derivative (EMD) vs Calcium hydroxide (CH)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 and 12 months
    Direct pulp capping; overall failure RR 1.00 (0.06 to 15.50) at 6/12 months (Garrocho-Rangel 2009); no pain/soft tissue/mobility/root resorption
    1 study · 90 participants
    GRADE not reported

Twin Block functional appliance vs Other functional appliances (Bionator, Herbst, R-appliance, Dynamax, Bite-Jumping)

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Twin Block functional appliance may leads to lower final ANB compared with other functional appliances (Bionator, Herbst, R-appliance, Dynamax,… (low certainty).

1 finding from 1 review

3Mix (ciprofloxacin + metronidazole + minocycline) vs Ciprofloxacin + ornidazole + minocycline

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

2% mepivacaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
    'Other comparisons with 100% success': IANB - Allegretti 2016 22/22 vs 22/22; Visconti 2016 21/21 vs 21/21. Both formulations 100% successful; no meta-analysis (no difference).
    2 studies · 43 participants
    GRADE not reported

Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth

Duration of treatment · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth)

The review found no eligible studies for this question.

1 finding from 1 review

6% HP gel in tray vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 6% HP gel in tray changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

1 finding from 1 review

Glutaraldehyde + calcium hydroxide (CH) vs Full strength formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + calcium hydroxide (CH) showed no clear difference in radiological failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, surface index D(M)FS · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFS at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review

Any form of one-to-one oral hygiene advice (OHA) vs No OHA

Gingivitis · Children or adults (fit and healthy, or with a well-defined medical condition)

It is very uncertain whether any form of one-to-one oral hygiene advice (OHA) changes periodontal health: gingivitis compared with no OHA (very low certainty).

1 finding from 1 review