Change in body weight as compared to placebo [kg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Serious adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension
Orlistat probably leads to higher serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
All adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension
It is very uncertain whether orlistat changes all adverse events compared with placebo (very low certainty).
1 finding from 1 review
Change in systolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Change in diastolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Change in body weight as compared to placebo [kg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Cardiovascular morbidity · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Cardiovascular morbidity Combined endpoint: necessity of reinstating antihypertensive therapy and severe cardiovascular complications · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Systolic blood pressure (mmHg), change from baseline · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Diastolic blood pressure (mmHg), change from baseline · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Change in weight (kg) · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Measures of air pollution exposure ( · healthy individuals and those with a pre‐existing health condition
1 finding from 1 review
no estimate extracted
173 participants
Very low
Health Service Utilisation · healthy individuals and those with a pre‐existing health condition
1 finding from 1 review
no estimate extracted
2948 participants
Very low
Respiratory exacerbations · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relapse · participants with depressive or anxiety disorders
It is very uncertain whether discontinuation by "tapering" changes relapse (as defined by study authors) (HR) compared with continuation (or usual care) (very low certainty).
1 finding from 1 review