It is very uncertain whether docetaxel changes overall survival ‐ Other comparisons compared with non‐docetaxel‐containing regimens (very low certainty).
Docetaxel probably leads to higher tumour response compared with non‐docetaxel‐containing regimens (moderate certainty).
Combination probably leads to lower overall survival compared with single‐agent chemotherapy (moderate certainty).
It is very uncertain whether docetaxel changes time to progression compared with non‐docetaxel‐containing regimens (very low certainty).
Docetaxel probably leads to lower progression‐free survival compared with non‐docetaxel‐containing regimens (moderate certainty).
It is very uncertain whether docetaxel changes progression‐free survival ‐ Substitutive comparisons compared with non‐docetaxel‐containing regimens (very low certainty).
Docetaxel showed no clear difference in treatment‐related death compared with non‐docetaxel‐containing regimens (moderate certainty).
Docetaxel showed no clear difference in treatment discontinuation due to toxicity compared with non‐docetaxel‐containing regimens (low certainty).
Combination leads to higher tumour response compared with single‐agent chemotherapy (high certainty).
Capecitabine showed no clear difference in overall Survival compared with 5‐FU‐containing regimens (moderate certainty).
It is very uncertain whether capecitabine changes tumour response compared with 5‐FU‐containing regimens (very low certainty).
It is very uncertain whether capecitabine changes time to progression compared with 5‐FU‐containing regimens (very low certainty).
It is very uncertain whether capecitabine changes progression‐free survival compared with 5‐FU‐containing regimens (very low certainty).
It is very uncertain whether capecitabine changes treatment‐related death compared with 5‐FU‐containing regimens (very low certainty).
Capecitabine showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (low certainty).
Oxaliplatin may leads to lower overall Survival compared with the same regimen including cisplatin (low certainty).
Oxaliplatin probably leads to higher tumour response compared with the same regimen including cisplatin (moderate certainty).
Oxaliplatin showed no clear difference in progression‐free survival compared with the same regimen including cisplatin (low certainty).
Oxaliplatin showed no clear difference in treatment‐related death compared with the same regimen including cisplatin (low certainty).
Combination probably leads to lower time to progression compared with single‐agent chemotherapy (moderate certainty).