Findings

What do systematic reviews say?

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

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No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Summary of findings: Low sodium intake vs high sodium intake

Adrenaline pg/mL · Participants with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 331 participants
Moderate

Summary of findings: Low sodium intake vs high sodium intake

Cholesterol mg/dL · Participants with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
28 studies · 917 participants
High

Summary of findings: Low sodium intake vs high sodium intake

Trigyceride mg/dL · Participants with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 712 participants
High

Summary of findings: Low sodium intake vs high sodium intake

White population, normotensive, DBP mmHg · White population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
96 studies · 6276 participants
High

Summary of findings: Low sodium intake vs high sodium intake

LDL‐cholesterol · Participants with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
18 studies · 696 participants
High

Summary of findings: Low sodium intake vs high sodium intake

White population, hypertensive, SBP mmHg · White population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
88 studies · 3998 participants
High

Summary of findings: Low sodium intake vs high sodium intake

White population, hypertensive, DBP mmHg · White population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
89 studies · 4032 participants
High

Summary of findings: Low sodium intake vs high sodium intake

Black population, normotensive, SBP mmHg · Black population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 253 participants
Low

Summary of findings: Low sodium intake vs high sodium intake

Black population, normotensive, DBP mmHg · Black population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 253 participants
Low

Summary of findings: Low sodium intake vs high sodium intake

Black population, hypertensive, SBP mmHg · Black population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 398 participants
Low

Summary of findings: Low sodium intake vs high sodium intake

Black population, hypertensive, DBP mmHg · Black population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 398 participants
Low

Summary of findings: Low sodium intake vs high sodium intake

Asian population, normotensive, SBP mmHg · Asian population with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 950 participants
Moderate

Daily conventionally fractionated radiotherapy vs supportive care

Overall survival · high‐grade glioma

Daily conventionally fractionated radiotherapy probably leads to higher overall survival compared with no radiotherapy (supportive care alone) (moderate certainty).

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
HR 2.01 [1.58, 2.55]
4 studies · 397 participants
Moderate

Daily conventionally fractionated radiotherapy vs supportive care

Adverse effects · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 289 participants
GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

Progression‐free survival · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

Quality of life · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival · high‐grade glioma

It is very uncertain whether hypofractionated radiotherapy changes overall survival compared with daily conventionally fractionated radiotherapy (very low certainty).

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
HR 0.95 [0.78, 1.17]
5 studies · 943 participants
Very low

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Adverse effects · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 848 participants
GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Progression‐free survival · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Quality of life · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 361 participants
GRADE not reported