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What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Triple therapy vs LABA/LAMA combination

Respiratory HRQoL measured by SGRQ, ≥ 4‐point decrease from baseline (lower scores indicate better HRQoL) · stable COPD

Triple therapy leads to higher respiratory HRQoL measured by SGRQ, ≥ 4‐point decrease from baseline… compared with LABA/LAMA combination (high certainty).

1 finding from 1 review