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Evidence found and GRADE certainty

407 questions · 418 findings · 14 reviews · Endodontics and dental trauma

No studies found 104 · 24.9%GRADE not reported 201 · 48.1%Very low 61 · 14.6%Low 41 · 9.8%Moderate 11 · 2.6%High 0 · 0%

Self-etch adhesive + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Calcium-enriched mixture (CEM) cement vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review

Biodentine vs Tempophore

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in clinical failure compared with tempophore; GRADE not reported.

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Zinc oxide and eugenol (ZOE) pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate/MTA pulpotomy showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

ProRoot MTA vs OrthoMTA

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

ProRoot MTA showed no clear difference in clinical failure compared with orthoMTA; GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Buffered glutaraldehyde

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 months
    Assessed pain, soft tissue, mobility, radiolucency, root resorption, pulp canal obliteration (Goyal 2016); no clinical/radiological failure outcome; pain, mobility, radiolucency, root resorption significantly favour MTA
    1 study · 60 participants
    GRADE not reported

Mineral trioxide aggregate (MTA) vs Diode laser

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 months
    Assessed pain, soft tissue, mobility, radiolucency, root resorption, premature tooth loss (Niranjani 2015); no clinical/radiological failure outcome; no significant differences (RR 0.33, 0.01 to 7.72)
    1 study · 40 participants
    GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Calcium-enriched mixture (CEM) cement vs Mineral trioxide aggregate (MTA)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review

ProRoot MTA vs RetroMTA

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

ProRoot MTA showed no clear difference in radiological failure compared with retroMTA; GRADE not reported.

1 finding from 1 review