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What do systematic reviews say?

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Evidence found and GRADE certainty

186 questions · 191 findings · 36 reviews · Headline outcomes only

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No studies found 19 · 9.9%GRADE not reported 13 · 6.8%Very low 68 · 35.6%Low 55 · 28.8%Moderate 26 · 13.6%High 10 · 5.2%

Intervention not reported

Change in measure of disease activity Disease Activity Score (DAS‐28‐ESR) at 12 weeks (0 to 10 score; lower score means less disease activity) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in measure of disease activity Disease Activity Score… (very low certainty).

1 finding from 1 review

Intervention not reported

Change in function Health Assessment Questionnaire (HAQ) at 12 weeks (0 to 3 score; lower score means better function) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in function Health Assessment Questionnaire (HAQ) at 12 weeks… (very low certainty).

1 finding from 1 review

Intervention not reported

Radiographic progression · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Short‐term serious adverse events · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Long‐term adverse effects or toxicity · people with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Withdrawals – overall (at 8 to 12 weeks) · people with rheumatoid arthritis

The intervention may leads to lower withdrawals – overall (at 8 to 12 weeks) (low certainty).

1 finding from 1 review