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What do systematic reviews say?

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Evidence found and GRADE certainty

184 questions · 199 findings · 25 reviews

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No studies found 45 · 22.6%GRADE not reported 10 · 5%Very low 48 · 24.1%Low 35 · 17.6%Moderate 42 · 21.1%High 19 · 9.5%

Treatment route: intravenous corticosteroid vs oral corticosteroid

Treatment failure Need for additional treatment · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Relapse Hospital readmission for COPD · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in relapse Hospital readmission for COPD compared with oral corticosteroid (moderate certainty).

1 finding from 1 review