Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

272 questions · 286 findings · 20 reviews · Schizophrenia

No studies found 49 · 17.1%GRADE not reported 30 · 10.5%Very low 88 · 30.8%Low 42 · 14.7%Moderate 73 · 25.5%High 4 · 1.4%

HALOPERIDOL vs RISPERIDONE

Adverse effects: specific ‐ acute dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RISPERIDONE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes adverse effects: any observed extrapyramidal symptoms ‐ short term… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs RISPERIDONE

Clinically important response (defined by study) ‐ short term (up to 12 weeks) decreased rate of BPRS score < 20% · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes clinically important response (defined by study) ‐ short term (up to… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs RISPERIDONE

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

COMPARISON 3. ARIPIPRAZOLE showed no clear difference in global state: No clinically significant response (as defined by the… compared with RISPERIDONE (low certainty).

1 finding from 1 review