Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

197 questions · 197 findings · 34 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 83 · 42.1%GRADE not reported 0 · 0%Very low 41 · 20.8%Low 38 · 19.3%Moderate 31 · 15.7%High 4 · 2%

Summary of findings: nitric oxide vs placebo

FEV1 (% predicted): mean change from baseline · children (12 or over) and young adults with cystic fibrosis

Summary of findings: nitric oxide showed no clear difference in respiratory function mean change in FEV1 % predicted from baseline compared with placebo (low certainty).

1 finding from 1 review

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review