Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

207 questions · 223 findings · 29 reviews · Headline outcomes only

No studies found 43 · 19.3%GRADE not reported 14 · 6.3%Very low 39 · 17.5%Low 67 · 30%Moderate 54 · 24.2%High 6 · 2.7%

Intervention not reported

ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis

The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Remission3 · patients with rheumatoid arthritis
1 finding from 1 review

Intervention not reported

Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis
1 finding from 1 review

Intervention not reported

Health‐Related Quality of Life at least 20% improvement · patients with rheumatoid arthritis

The intervention showed no clear difference in health‐Related Quality of Life at least 20% improvement (moderate certainty).

1 finding from 1 review

Intervention not reported

Radiographic Progression Increase in erosion scores of > 3 units · patients with rheumatoid arthritis

The intervention probably leads to lower radiographic Progression Increase in erosion scores of > 3 units (moderate certainty).

1 finding from 1 review

Intervention not reported

Discontinuations due to adverse events · patients with rheumatoid arthritis

The intervention leads to higher discontinuations due to adverse events (high certainty).

1 finding from 1 review

Intervention not reported

Serious Adverse Events · patients with rheumatoid arthritis

The intervention showed no clear difference in serious Adverse Events (moderate certainty).

1 finding from 1 review

MTX treated vs no MTX treated

Withdrawals due to any reason · Patients with AS

MTX treated showed no clear difference in withdrawal for any reason compared with no MTX treated (low certainty).

1 finding from 1 review