Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

188 questions · 193 findings · 30 reviews · Schizophrenia

No studies found 54 · 28%GRADE not reported 23 · 11.9%Very low 50 · 25.9%Low 47 · 24.4%Moderate 15 · 7.8%High 4 · 2.1%

SHORT vs LONG HOSPITAL STAY

General functioning: Unemployed, unable to housekeep or unknown employment status ‐ by 2 years Number of participants with poor occupational functioning in 2 years · patients with people with severe mental illnesses

It is very uncertain whether SHORT changes general functioning: Unemployed, unable to housekeep or unknown… compared with LONG HOSPITAL STAY (very low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate showed no clear difference in no clinically important change Number of people whose PANSS score… compared with risperidone long‐acting injection (low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

Relapse: recurrence of psychotic symptoms Reported by trial author as adverse event · patients with schizophrenia

Paliperidone palmitate showed no clear difference in relapse: recurrence of psychotic symptoms Reported by trial authors… compared with risperidone long‐acting injection (moderate certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

Leaving the study early ‐ lack of efficacy Reported by trial author · patients with schizophrenia

Paliperidone palmitate probably leads to higher leaving the study early ‐ lack of efficacy Reported by trial author compared with risperidone long‐acting injection (moderate certainty).

1 finding from 1 review