Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 19,475 (3 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in any cancer risk No. of participants: 19,475 (3 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Mortality: all cancers · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes cancer mortality risk No. of participants: 183,863 (7 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes colorectal cancer risk No. of participants: 712,746 (6 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes lung cancer risk No. of participants: 371,067 (11 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes breast cancer risk (women) No. of participants: 169,028 (8… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review