Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

442 questions · 468 findings · 55 reviews

No studies found 96 · 20.5%GRADE not reported 54 · 11.5%Very low 172 · 36.8%Low 87 · 18.6%Moderate 40 · 8.5%High 19 · 4.1%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review