What do systematic reviews say?

Budesonide vs placebo

It is very uncertain whether budesonide changes withdrawals due to adverse events compared with placebo (very low certainty).

• Interventions for treating collagenous colitis 2017 · Cochrane Headline outcomes only
  RR 0.97 [0.43, 2.17]
  5 studies · 290 participants
  Very low

Budesonide vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Budesonide showed no clear difference in withdrawals due to adverse events compared with mesalazine (low certainty).

• Interventions for treating collagenous colitis 2017 · Cochrane Headline outcomes only
  RR 0.09 [0.01, 1.65]
  1 study · 55 participants
  Low

Nebulized budesonide vs viscous budesonide

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low

Oral viscous budesonide vs swallowed fluticasone

Oral viscous budesonide showed no clear difference in withdrawals due to adverse events at 8 weeks compared with swallowed fluticasone (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.42, 2.32]
  1 study · 129 participants
  Low

Azathioprine vs budesonide

It is very uncertain whether azathioprine changes withdrawals due to adverse events compared with budesonide (very low certainty).

• Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
  RR 5.13 [0.25, 103.43]
  1 study · 77 participants
  Very low

Six‐food elimination diet vs swallowed fluticasone compared to swallowed budesonide compared to oral viscous budesonide

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found