Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 3 · 60%High 0 · 0%

Withdrawal due to disease worsening · Patients with active Crohn's disease

It is very uncertain whether budesonide 9 mg changes withdrawal due to disease worsening compared with conventional steroids (very low certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1 [0.07, 14.55]
1 study · 30 participants
Very low

Withdrawal due to disease worsening · Patients with active Crohn's disease

Budesonide 9 mg probably leads to lower withdrawal due to disease worsening compared with mesalamine (moderate certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.35 [0.18, 0.69]
1 study · 182 participants
Moderate

Withdrawal due to disease worsening · Patients with active Crohn's disease

Budesonide 3 mg showed no clear difference in withdrawal due to disease worsening compared with placebo (moderate certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.92 [0.64, 1.33]
1 study · 133 participants
Moderate

Withdrawal due to disease worsening · Patients with active Crohn's disease

Budesonide 9 mg showed no clear difference in withdrawal due to disease worsening compared with placebo (low certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.53 [0.22, 1.29]
3 studies · 379 participants
Low

Withdrawal due to disease worsening · Patients with active Crohn's disease

Budesonide 15 mg probably leads to lower withdrawal due to disease worsening compared with placebo (moderate certainty).

1 finding from 1 review

Budesonide for induction of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.57 [0.36, 0.89]
2 studies · 181 participants
Moderate