Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Methotrexate vs 6‐MP or azathioprine

Withdrawals due to adverse events · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes withdrawal due to adverse event (Maté‐Jiménez 2000) compared with 6‐MP or azathioprine (very low certainty).

1 finding from 1 review

Methotrexate for induction of remission in refractory Crohn's disease 2014 · Cochrane Headline outcomes only
RR 2.13 [0.22, 21.17]
1 study · 31 participants
Very low

Methotrexate vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes withdrawal due to adverse event (Maté‐Jiménez 2000) compared with 5‐ASA (very low certainty).

1 finding from 1 review

Methotrexate for induction of remission in refractory Crohn's disease 2014 · Cochrane Headline outcomes only
RR 2.5 [0.14, 46.14]
1 study · 22 participants
Very low