What do systematic reviews say?

Continuous platinum infusion vs bolus platinum infusion

• Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  Low

Amifostine vs no otoprotective intervention

Amifostine showed no clear difference in tumour response with intra‐arterial platinum (good and partial… compared with no otoprotective intervention (low certainty).

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 1.6 [0.97, 2.63]
  1 study · 27 participants
  Low

Sodium thiosulfate vs no otoprotective intervention

Sodium thiosulfate showed no clear difference in tumour response with intravenous platinum (complete and partial… compared with no otoprotective intervention (low certainty).

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 1.06 [0.98, 1.15]
  1 study · 108 participants
  Low

Sodium thiosulfate vs no otoprotective intervention

The review found no eligible studies for this question.

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Amifostine vs no otoprotective intervention

The review found no eligible studies for this question.

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found