What do systematic reviews say?

Silodosin vs naftopidil

Silodosin showed no clear difference in treatment withdrawal due to any reason compared with naftopidil (low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.25 [0.81, 1.93]
  4 studies · 659 participants
  Low

Silodosin vs alfuzosin

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low

Silodosin vs placebo

Silodosin showed no clear difference in treatment withdrawal due to any reason compared with placebo (low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.08 [0.7, 1.66]
  3 studies · 1703 participants
  Low

Silodosin vs tamsulosin

It is very uncertain whether silodosin changes treatment withdrawal due to any reason compared with tamsulosin (very low certainty).

• Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2017 · Cochrane Headline outcomes only
  RR 1.02 [0.62, 1.69]
  10 studies · 1573 participants
  Very low