Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether phenobarbital changes treatment failure To discharge compared with chlorpromazine (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.55 [0.33, 0.92]
2 studies · 138 participants
Very low

Treatment failure To discharge · newborn infants with opioid withdrawal

Opioid probably leads to lower treatment failure To discharge compared with chlorpromazine (moderate certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.08 [0.01, 0.62]
1 study · 90 participants
Moderate