What do systematic reviews say?

Citrate vs unfractionated heparin

Citrate showed no clear difference in treatment cessation due to adverse events compared with unfractionated heparin (low certainty).

• Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
  RR 0.47 [0.15, 1.49]
  3 studies · 412 participants
  Low