Combination showed no clear difference in treatment‐related death compared with single‐agent chemotherapy (moderate certainty).
Irinotecan showed no clear difference in treatment‐related death compared with non‐irinotecan‐containing regimens (low certainty).
Docetaxel showed no clear difference in treatment‐related death compared with non‐docetaxel‐containing regimens (moderate certainty).
It is very uncertain whether capecitabine changes treatment‐related death compared with 5‐FU‐containing regimens (very low certainty).
Oxaliplatin showed no clear difference in treatment‐related death compared with the same regimen including cisplatin (low certainty).
It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment‐related death compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).
S‐1 showed no clear difference in treatment‐related deaths compared with 5‐FU‐containing regimens (moderate certainty).