What do systematic reviews say?

OFS vs no OFS

OFS may leads to higher toxicity ‐ bone health (osteoporosis defined by a T score < ‐2.5) compared with no OFS (low certainty).

• Ovarian suppression for adjuvant treatment of hormone receptor‐positive early breast cancer 2020 · Cochrane Headline outcomes only
  RR 1.66 [1.1, 2.5]
  1 study · 2011 participants
  Low