What do systematic reviews say?

Summary of findings: Evening RT vs morning RT

Summary of findings: Evening RT may leads to lower acute and late GI toxicity (grade 2+) compared with morning RT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.51 [0.34, 0.76]
  2 studies · 294 participants
  Low

Summary of findings: Octreotide vs placebo

The review found no eligible studies for this question.

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Misoprostol vs placebo

Summary of findings: Misoprostol showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.38 [0.76, 2.51]
  1 study · 100 participants
  Low

Summary of findings: Conformal RT vs conventional dose RT

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 307 participants
  High

Sucralfate vs placebo

Summary of findings: Sucralfate showed no clear difference in acute and late GI toxicity (grade 2+) [acute = during RT; late = 6… compared with placebo (moderate certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.07 [0.83, 1.39]
  1 study · 335 participants
  Moderate

Corticosteroids vs placebo

It is very uncertain whether summary of findings: Corticosteroids changes acute and late GI toxicity (grade 2+) compared with placebo (very low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.85 [0.62, 1.15]
  1 study · 126 participants
  Very low

Summary of findings: Sodium butyrate vs placebo

Summary of findings: Sodium butyrate showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.91 [0.41, 1.98]
  1 study · 79 participants
  Moderate

Summary of findings: Magnesium oxide vs placebo

Summary of findings: Magnesium oxide showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.7 [0.87, 3.31]
  1 study · 92 participants
  Moderate

Summary of findings: Aminosalicylates vs placebo

Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.02 [1.22, 1.45]
  2 studies · 143 participants
  Moderate

Summary of findings: Reduced dose volume vs standard dose volume

Summary of findings: Reduced dose volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with standard dose volume (moderate certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 1.21 [0.81, 1.81]
  1 study · 211 participants
  Moderate

Summary of findings: Higher bladder volume vs lower bladder volume

Summary of findings: Higher bladder volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with lower bladder volume (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 2.22 [0.62, 7.93]
  1 study · 110 participants
  Low