What do systematic reviews say?

First‐line thiazides vs ACE inhibitor

First‐line thiazides probably leads to lower total stroke Duration: 2.6 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.8, 0.99]
  3 studies · 30900 participants
  Moderate