Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 23 findings · 2 reviews

No studies found 1 · 4.3%GRADE not reported 16 · 69.6%Very low 3 · 13%Low 2 · 8.7%Moderate 1 · 4.3%High 0 · 0%

Altered fractionation radiotherapy (hyperfractionated and/or accelerated) vs Conventional (standard) fractionation radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated/accelerated radiotherapy showed no clear difference in total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review