Findings

What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Musculoskeletal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 1 · 100%

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
RR 1.27 [1.15, 1.41]
9 studies · 2101 participants
High